Article
Novel associations among HLA-DQA1 and -DQB1 alleles, revealed by high-resolution sequence-based typing (SBT).
Tissue antigens - 1 Mar 2000
Pera C, Delfino L, Longo A, Pistillo M P, Ferrara G B
Abstract excerpt
Althought it is a valuable tool for the identification of HLA alleles, sequence-based typing (SBT) presents difficulties when used to determine HLA-DQA1 and -DQB1 alleles. Specifically, some HLA-DQA1 alleles have a three-base deletion at codon 56 of exon 2 that interferes with the sequencing read. Moreover, the frequently used primers for HLA-DQB1 may co-amplify the HLA-DQB2 pseudogene. To overcome these...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
