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Article

5-Azacytidine and RNA secondary structure increase the retrovirus mutation rate.

Journal of virology - 1 May 1992

Pathak V K, Temin H M

Abstract excerpt

A broad spectrum of mutations occurs at a high rate during a single round of retrovirus replication (V.K. Pathak and H. M. Temin, Proc. Natl. Acad. Sci. USA 87:6019-6023, 1990). We have now determined that this high rate of spontaneous mutation can be further increased by 5-azacytidine (AZC) treatment or by regions of potential RNA secondary structure. We found a 13-fold increase in the mutation rate after AZC...

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Identifiers

PMID: 1373201
DOI: 10.1128/JVI.66.5.3093-3100.1992
PMCID: PMC241071

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