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Article

5-Azacytidine and RNA secondary structure increase the retrovirus mutation rate.

Journal of virology - 1 May 1992

Pathak V K, Temin H M

Abstract excerpt

A broad spectrum of mutations occurs at a high rate during a single round of retrovirus replication (V.K. Pathak and H. M. Temin, Proc. Natl. Acad. Sci. USA 87:6019-6023, 1990). We have now determined that this high rate of spontaneous mutation can be further increased by 5-azacytidine (AZC) treatment or by regions of potential RNA secondary structure. We found a 13-fold increase in the mutation rate after AZC...

Topics

Animals
Azacitidine
Base Sequence
Cell Line
Chromosome Mapping
Genetic Vectors
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Proviruses
Reticuloendotheliosis virus
Retroviridae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes, Helper-Inducer

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Identifiers

PMID: 1373201
DOI: 10.1128/JVI.66.5.3093-3100.1992
PMCID: PMC241071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1373201-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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