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Article

Hallmarks of telomeres in ageing research

1 Jan 2007

Abstract excerpt

Telomeres are repetitive DNA sequences at the ends of linear chromosomes. Telomerase, a cellular reverse transcriptase, helps maintain telomere length in human stem cells, reproductive cells and cancer cells by adding TTAGGG repeats onto the telomeres. However, most normal human cells do not express telomerase and thus each time a cell divides some telomeric sequences are lost. When telomeres in a subset of cells...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 17200948
DOI: 10.1002/path.2090

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