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Role of Telomerase in Normal and Cancer Cells

1 Jul 2000

Abstract excerpt

Shortening of the telomeric DNA at chromosome ends is postulated to limit the lifespan of human cells. In contrast, activation of telomerase, the enzyme that synthesizes telomeric DNA, is proposed to be an essential step in cancer cell immortalization and cancer progression. This review discusses the structure and function of telomeres and telomerase, the role of telomerase in cell immortalization, and the...

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PMID: 10893296
DOI: 10.1200/jco.2000.18.13.2626

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