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Article

Role of telomerase in cellular proliferation and cancer

1 Jul 1999

Abstract excerpt

Telomerase is a cellular reverse transcriptase that helps to provide genomic stability in highly proliferative normal, immortal, and tumor cells by maintaining the integrity of the chromosome ends, the telomeres. The activity of telomerase is associated with the majority of malignant human cancers. Telomerase or another mechanism for telomere maintenance is required for continuous tumor cell proliferation....

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PMID: 10362013
DOI: 10.1002/(sici)1097-4652(199907)180:1<10::aid-jcp2>3.0.co;2-d

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