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Article

Adenovirus-Mediated p14ARF Gene Transfer in Human Mesothelioma Cells

19 Apr 2000

Abstract excerpt

BACKGROUND: The p14(ARF) protein encoded by the INK4a/ARF locus promotes degradation of the MDM2 protein and thus prevents the MDM2-mediated inhibition of p53. Homozygous deletion of the INK4a/ARF locus is common in human mesothelioma and may result in the loss of p14(ARF) and the inactivation of p53. We designed this study to evaluate the biologic and potential therapeutic roles of p14(ARF) expression in...

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PMID: 10772681
DOI: 10.1093/jnci/92.8.636

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