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Article

Gene therapy of established mesothelioma xenografts with recombinant p16INK4a adenovirus.

Cancer gene therapy - 1 Nov 2000

Frizelle S P, Rubins J B, Zhou J X, Curiel D T, Kratzke R A

Abstract excerpt

The absence of expression of the p16INK4a gene product is observed in virtually all mesothelioma tumors and cell lines, whereas wild-type pRB expression is maintained. We have examined the potential therapeutic role of re-expressing the p16INK4a gene product in mice with established human mesothelioma xenografts. Experiments using Adp16 treatments in mesothelioma xenografts demonstrated prolonged survival and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11129284
DOI: 10.1038/sj.cgt.7700241

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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