Article
Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma.
Cell cycle (Georgetown, Tex.) - 1 Jan 2014
Di Marzo Domenico, Forte Iris Maria, Indovina Paola, Di Gennaro Elena, Rizzo Valeria, Giorgi Francesca, Mattioli Eliseo, Iannuzzi Carmelina Antonella, Budillon Alfredo, Giordano Antonio, Pentimalli Francesca
Abstract excerpt
Malignant mesothelioma, a very aggressive tumor associated to asbestos exposure, is expected to increase in incidence, and unfortunately, no curative modality exists. Reactivation of p53 is a new attractive antitumoral strategy. p53 is rarely mutated in mesothelioma, but it is inactivated in most tumors by the lack of p14(ARF). Here, we evaluated the feasibility of this approach in pleural mesothelioma by testing...
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