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Cul4A is an oncogene in malignant pleural mesothelioma

19 Nov 2009

Abstract excerpt

Cullin 4A (Cul4A) is important in cell survival, development, growth and the cell cycle, but its role in mesothelioma has not been studied. For the first time, we identified amplification of the Cul4A gene in four of five mesothelioma cell lines. Consistent with increased Cul4A gene copy number, we found that Cul4A protein was overexpressed in mesothelioma cells as well. Cul4A protein was also overexpressed in...

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PMID: 19929949
DOI: 10.1111/j.1582-4934.2009.00971.x

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