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Article

Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity.

Development (Cambridge, England) - 1 May 2000

Yu K, Srinivasan S, Shimmi O, Biehs B, Rashka K E, Kimelman D, O'Connor M B, Bier E

Abstract excerpt

Structurally unrelated neural inducers in vertebrate and invertebrate embryos have been proposed to function by binding to BMP4 or Dpp, respectively, and preventing these homologous signals from activating their receptor(s). In this study, we investigate the functions of various forms of the Drosophila Sog protein using the discriminating assay of Drosophila wing development. We find that misexpression of...

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Source

Identifiers

PMID: 10769238
DOI: 10.1242/dev.127.10.2143

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity.PMID 10769238Read ↗

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A positive role for Short gastrulation in modulating BMP signaling during dorsoventral patterning in the Drosophila embryo.Semantic proximity Read ↗

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The pro-BMP activity of Twisted gastrulation is independent of BMP binding.Semantic proximity Read ↗

Integrins modulate Sog activity in the Drosophila wing.Semantic proximity Read ↗

The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development.Semantic proximity Read ↗

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Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms.Semantic proximity Read ↗

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