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Article

Sog/Chordin is required for ventral-to-dorsal Dpp/BMP transport and head formation in a short germ insect.

Proceedings of the National Academy of Sciences of the United States of America - 31 Oct 2006

van der Zee Maurijn, Stockhammer Oliver, von Levetzow Cornelia, Nunes da Fonseca Rodrigo, Roth Siegfried

Abstract excerpt

Bone morphogenetic protein (BMP) signaling plays a major role in dorsoventral patterning in vertebrates and in Drosophila. Remarkably, in Tribolium, a beetle with an ancestral type of insect development, early BMP/dpp exhibits differential expression along the anteroposterior axis. However, the BMP/Dpp inhibitor Sog/chordin is expressed ventrally and establishes a dorsal domain of BMP/Dpp activity by transporting...

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Identifiers

PMID: 17050690
DOI: 10.1073/pnas.0605154103
PMCID: PMC1637578

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