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Article

Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.

The Journal of biological chemistry - 30 Jun 2000

Koipally J, Georgopoulos K

Abstract excerpt

We have previously shown that Ikaros can repress transcription through the recruitment of histone deacetylase complexes. Here we provide evidence that Ikaros can also repress transcription through its interactions with the co-repressor, C-terminal binding protein (CtBP). CtBP interacts with Ikaros isoforms through a PEDLS motif present at the N terminus of these proteins but not with homologues like Aiolos which...

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Identifiers

PMID: 10766745
DOI: 10.1074/jbc.M000254200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.PMID 10766745Read ↗

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