Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ikaros-CtIP Interactions Do Not Require C-terminal Binding Protein and Participate in a Deacetylase-independent Mode of Repression

1 Jun 2002

Abstract excerpt

Ikaros and Aiolos are Kruppel zinc finger proteins that play key roles in hemo-lymphoid development and homeostasis. We have previously shown that they can repress transcription through the recruitment of histone deacetylases (HDACs). Here, we provide the first functional evidence that these proteins can also repress gene function in a manner that does not require deacetylase activity. This functionality can be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Peptidase Inhibition and Analysis
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11959865
DOI: 10.1074/jbc.m202079200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ikaros-CtIP Interactions Do Not Require C-terminal Binding Protein and Participate in a Deacetylase-independent Mode of RepressionPMID 11959865Read ↗

Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.Semantic proximity Read ↗

Conserved helical motifs in the Ikaros IDR mediate NuRD interaction and transcriptional repressionSemantic proximity Read ↗

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development.Semantic proximity Read ↗

IKAROS and AIOLOS activate AP-1 transcriptional complexes and are essential for natural killer cell developmentSemantic proximity Read ↗

Loss-of-function mutation in <i>IKZF2</i> leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cellsSemantic proximity Read ↗

Conserved helical motifs in the IKZF1 disordered region mediate NuRD interaction and transcriptional repressionSemantic proximity Read ↗

Transcriptional regulation of the Ikzf1 locusSemantic proximity Read ↗

Critical roles of Ikaros and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Regulator of myeloid differentiation and function: The secret life of IkarosSemantic proximity Read ↗

Transcriptional circuits in B cell transformationSemantic proximity Read ↗

Human Ikaros Function in Activated T Cells Is Regulated by Coordinated Expression of Its Largest IsoformsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.