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Article

Identification of a genetic locus modulating splenomegaly induced by granulocyte colony-stimulating factor in mice.

Leukemia - 1 Apr 2000

Roberts A W, Hasegawa M, Metcalf D, Foote S J

Abstract excerpt

Clinically detectable splenomegaly and splenic rupture are uncommon but potentially life-threatening consequences of G-CSF administration. Increased spleen size in mice injected with G-CSF is a complex genetic trait amenable to investigation in experimental inter-strain crosses by quantitative trait analysis. A quantitative trait locus (QTL) with highly significant linkage (LOD 7.9) for splenomegaly was...

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PMID: 10764151
DOI: 10.1038/sj.leu.2401735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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