Article
The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients.
PloS one - 1 Jan 2011
Roth Eva K, Hirtz Stephanie, Duerr Julia, Wenning Daniel, Eichler Irmgard, Seydewitz Hans H, Amaral Margarida D, Mall Marcus A
Abstract excerpt
BACKGROUND: The identification of strategies to improve mutant CFTR function remains a key priority in the development of new treatments for cystic fibrosis (CF). Previous studies demonstrated that the K⁺ channel opener 1-ethyl-2-benzimidazolone (1-EBIO) potentiates CFTR-mediated Cl⁻ secretion in cultured cells and mouse colon. However, the effects of 1-EBIO on wild-type and mutant CFTR function in native human...
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