Determinants of mild clinical symptoms in cystic fibrosis patients. Residual chloride secretion measured in rectal biopsies in relation to the genotype.

doi:10.1172/JCI116993

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Article

Determinants of mild clinical symptoms in cystic fibrosis patients. Residual chloride secretion measured in rectal biopsies in relation to the genotype.

The Journal of clinical investigation - 1 Feb 1994

Veeze H J, Halley D J, Bijman J, de Jongste J C, de Jonge H R, Sinaasappel M

Abstract excerpt

Previous Ussing chamber measurements of secretagogue-provoked changes in short circuit current in rectal suction biopsies of cystic fibrosis (CF) patients showed that in a minority of patients chloride secretion in response to cholinergic agonists is reduced but not completely absent. To assess a possible relationship between this phenomenon and both the genotype and the phenotype, we performed Ussing chamber...

Topics

Adolescent
Adult
Aged
Alleles
Biopsy
Carbachol
Child
Child, Preschool
Chlorides
Cystic Fibrosis
DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epithelium

Evoked Potentials

Female

Genotype

Humans

Infant

Intestinal Mucosa

Source

Open in PubMed Open full text

Identifiers

PMID: 8113384
DOI: 10.1172/JCI116993
PMCID: PMC293855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8113384-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Determinants of mild clinical symptoms in cystic fibrosis patients. Residual chloride secretion measured in rectal biopsies in relation to the genotype.PMID 8113384Read ↗

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