Article
Effect of genistein on native epithelial tissue from normal individuals and CF patients and on ion channels expressed in Xenopus oocytes.
British journal of pharmacology - 1 Aug 2000
Mall M, Wissner A, Seydewitz H H, Hübner M, Kuehr J, Brandis M, Greger R, Kunzelmann K
Abstract excerpt
The flavonoid genistein has been shown to activate a Cl(-) conductance in various cell types expressing CFTR. We examined if similar effects can be observed when genistein is applied to native ex vivo tissues from human respiratory tract and rectum. We further compared the effects when genistein was applied to oocytes of Xenopus laevis expressing CFTR. In oocytes, both wtCFTR and DeltaF508-CFTR were activated by...
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