Article

Optimization of Anticodon Edited Transfer RNAs (ACE-tRNAs) Function in Translation for Suppression of Nonsense Mutations

2024-01-12

Abstract excerpt

<h4>SUMMARY</h4> Nonsense suppressor tRNAs or AntiCodon-Edited tRNAs (ACE-tRNAs) have long been envisioned as a therapeutic approach to overcome genetic diseases resulting from the introduction of premature stop codons (PTCs). The ACE-tRNA approach for the rescue of PTCs has been hampered by ineffective delivery through available modalities for gene therapy. Here we have screened a series of ACE-tRNA expression c...

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Literature Corpus work: ef364b15-2907-52aa-88e3-3992b697daf4
DOI: 10.1101/2024.01.11.575297

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