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Article

Dominant Role of Host Selective Pressure in Driving Hepatitis C Virus Evolution in Perinatal Infection

1 May 2000

Abstract excerpt

The dynamics of the genetic diversification of hepatitis C virus (HCV) populations was addressed in perinatal infection. Clonal sequences of hypervariable region 1 of the putative E2 envelope protein of HCV were obtained from four HCV-infected newborns (sequential samples spanning a period of 6 to 13 months after birth) and from their mothers (all samples collected at delivery). The data show that the variants...

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PMID: 10756048
DOI: 10.1128/jvi.74.9.4327-4334.2000

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