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Article

Evolution of hepatitis C viral quasispecies and hepatic injury in perinatally infected children followed prospectively

17 May 2006

Abstract excerpt

Perinatal infection with hepatitis C virus (HCV) is characterized by a wide range of alanine aminotransferase (ALT) levels. The mechanisms responsible for this variability are unknown. We examined whether the evolution of the HCV quasispecies was associated with different ALT profiles in perinatally infected children. Sequences within HCV envelope 1 and 2 genes, inclusive of the hypervariable region 1, the viral...

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PMID: 16707577
DOI: 10.1073/pnas.0602546103

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