Article
p53 codon 72 polymorphism and susceptibility to skin cancer after renal transplantation.
Transplantation - 15 Mar 2000
Marshall S E, Bordea C, Wojnarowska F, Morris P J, Welsh K I
Abstract excerpt
BACKGROUND: Infection with human papillomavirus (HPV) is an important risk factor for the development of skin cancer after renal transplantation. It has recently been suggested that degradation of the tumor suppressor gene p53 is an important mechanism for human papillomavirus-induced carcinogenesis. A common genomic polymorphism occurs at codon 72 of the p53 gene, and in vitro the codon 72Arg variant appears to...
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