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Article

Osteoblastic differentiation and P-glycoprotein multidrug resistance in a murine osteosarcoma model.

British journal of cancer - 1 Apr 2000

Takeshita H, Kusuzaki K, Murata H, Suginoshita T, Hirata M, Hashiguchi S, Ashihara T, Gebhardt M C, Mankin H J, Hirasawa Y

Abstract excerpt

A recent study of multidrug resistance (MDR) 1 gene transfected osteosarcoma cells found a cause-effect relationship between increased expression of P-glycoprotein (P-gp) and a low aggressive phenotype. However, several experimental and clinical studies have observed contradictory findings in that P-gp expression has been associated with tumour progression. In the present study, we characterized P-gp-positive and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10755409
DOI: 10.1054/bjoc.1999.1099
PMCID: PMC2374486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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