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Article

Multidrug resistance phenotype in high grade soft tissue sarcoma: correlation of P-glycoprotein immunohistochemistry with pathologic response to chemotherapy.

Cancer - 15 Sept 1999

Jimenez R E, Zalupski M M, Frank J J, Du W, Ryan J R, Lucas D R

Abstract excerpt

BACKGROUND: P-glycoprotein-mediated drug efflux has been implicated as an important mechanism of multidrug resistance (MDR) in cancer. Its role in chemotherapy resistance in soft tissue sarcoma is unclear. METHODS: Tumor specimens prior to and following neoadjuvant chemotherapy from 29 cases of high grade soft tissue sarcoma were analyzed with 2 monoclonal antibodies (C494 and JSB-1) that recognize different...

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Identifiers

PMID: 10491523
DOI: 10.1002/(sici)1097-0142(19990915)86:6<976::aid-cncr12>3.0.co;2-3

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