Article
Genetic reassortment and patch repair by recombination in retroviruses.
Journal of biomedical science - 1 Jan 2000
Mikkelsen J G, Pedersen F S
Abstract excerpt
Retroviral particles contain a diploid RNA genome which serves as template for the synthesis of double-stranded DNA in a complex process guided by virus-encoded reverse transcriptase. The dimeric nature of the genome allows the proceeding polymerase to switch templates during copying of the copackaged RNA molecules, leading to the generation of recombinant proviruses that harbor genetic information derived from...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
