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Mechanisms of Retroviral Recombination

1 Dec 2001

Abstract excerpt

Recombination is a major source of genetic variability in retroviruses. Each viral particle contains two single-stranded genomic RNAs. Recombination mostly results from a switch in template between these two RNAs during reverse transcription. Here we emphasize the main mechanisms underlying recombination that are emerging from recent advances in biochemical and cell culture techniques. Increasing evidence...

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Identifiers

PMID: 11700285
DOI: 10.1146/annurev.genet.35.102401.090551

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