Article
Generation of diversity in retroviruses.
Annual review of genetics - 1 Jan 1990
Katz R A, Skalka A M
Abstract excerpt
Retroviruses are unique in that their propagation includes transfer of genetic information from RNA to DNA. Two enzymes (RT and RNA polymerase II) that participate in their replication process do not encode editing functions and are thus "error prone." Current estimates indicate that up to one nucleotide substitution per genome occurs per retrovirus replication cycle. In addition, rearrangements can occur during...
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