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Article

Unfolding pathways of individual bacteriorhodopsins.

Science (New York, N.Y.) - 7 Apr 2000

Oesterhelt F, Oesterhelt D, Pfeiffer M, Engel A, Gaub H E, Müller D J

Abstract excerpt

Atomic force microscopy and single-molecule force spectroscopy were combined to image and manipulate purple membrane patches from Halobacterium salinarum. Individual bacteriorhodopsin molecules were first localized and then extracted from the membrane; the remaining vacancies were imaged again. Anchoring forces between 100 and 200 piconewtons for the different helices were found. Upon extraction, the helices were...

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Identifiers

PMID: 10753119
DOI: 10.1126/science.288.5463.143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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