Article
Steered molecular dynamics simulations of a type IV pilus probe initial stages of a force-induced conformational transition.
PLoS computational biology - 1 Apr 2013
Baker Joseph L, Biais Nicolas, Tama Florence
Abstract excerpt
Type IV pili are long, protein filaments built from a repeating subunit that protrudes from the surface of a wide variety of infectious bacteria. They are implicated in a vast array of functions, ranging from bacterial motility to microcolony formation to infection. One of the most well-studied type IV filaments is the gonococcal type IV pilus (GC-T4P) from Neisseria gonorrhoeae, the causative agent of gonorrhea....
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