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Article

Unfolding mechanics of multiple OspA substructures investigated with single molecule force spectroscopy.

Journal of molecular biology - 7 Nov 2003

Hertadi Rukman, Gruswitz Franz, Silver Lin, Koide Akiko, Koide Shohei, Arakawa Hideo, Ikai Atsushi

Abstract excerpt

We investigated mechanical unfolding of Borrelia burgdorferi outer surface protein A (OspA), a Lyme disease antigen containing a unique single-layer beta-sheet, with atomic force microscopy (AFM). We mechanically stretched a monomeric unit, rather than a tandem repeat, by pulling it from its N and C-terminal residues without using intervening polymer as a spacer. We detected two peaks in the force-extension...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14583195
DOI: 10.1016/j.jmb.2003.09.010

Genes

AFM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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