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Article

Structural insights into retinitis pigmentosa from unfolding simulations of rhodopsin mutants.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2010

Fanelli Francesca, Seeber Michele

Abstract excerpt

Disease-causing missense mutations in membrane proteins, such as rhodopsin mutations associated with the autosomal dominant form of retinitis pigmentosa (ADRP), are often linked to defects in folding and/or trafficking. The mechanical unfolding of wild-type rhodopsin was compared with that of 20 selected ADRP-linked mutants more or less defective in folding and retinal binding. Rhodopsin fold is characterized by...

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Identifiers

PMID: 20395457
DOI: 10.1096/fj.09-151084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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