Polymorphism of the ACE gene in Henoch-Schönlein purpura nephritis.

doi:10.1007/s004670050045

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Article

Polymorphism of the ACE gene in Henoch-Schönlein purpura nephritis.

Pediatric nephrology (Berlin, Germany) - 1 Mar 2000

Dudley J, Afifi E, Gardner A, Tizard E J, McGraw M E

Abstract excerpt

Individuals with IgA nephropathy (IgAN) who are homozygous for the deletion (D) polymorphism of the gene for angiotensin converting enzyme (ACE) are reported to be at increased risk of progressive renal damage. Since IgAN and Henoch-Schönlein purpura with associated nephritis (HSPN) share a common aetiology, we have investigated this influence in 31 children with HSPN. The distribution of genotypes was as...

Topics

Child
Child, Preschool
Edema
Gene Frequency
Genotype
Humans
IgA Vasculitis
Kidney
Nephritis
Peptidyl-Dipeptidase A
Polymorphism, Genetic

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Open in PubMed

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PMID: 10752761
DOI: 10.1007/s004670050045

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