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Article

The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM.

Clinical nephrology - 1 Mar 1999

Vleming L J, van der Pijl J W, Lemkes H H, Westendorp R G, Maassen J A, Daha M R, van Es L A, van Kooten C

Abstract excerpt

BACKGROUND: The insertion-deletion (I/D) polymorphism of the angiotensin converting enzyme gene is a diallelic polymorphism that constitutes a genetic influence on the progression of renal diseases such as IgA nephropathy. Patients with the DD genotype have an accelerated progression towards end stage renal failure in these diseases. The role of the I/D polymorphism in the pathogenesis of diabetic nephropathy in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10099885

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM.PMID 10099885Read ↗

Excess of DD homozygotes in haemodialysed patients with type II diabetes. The Diabetic Nephropathy Study Group.Semantic proximity Read ↗

The DD genotype of the ACE gene polymorphism is associated with diabetic nephropathy in the type-1 diabetics.Semantic proximity Read ↗

Angiotensin I converting enzyme gene polymorphism and diabetic nephropathy in type II diabetes.Semantic proximity Read ↗

Evaluation of risk factors for the development of nephropathy in patients with IDDM: insertion/deletion angiotensin converting enzyme gene polymorphism, hypertension and metabolic control.Semantic proximity Read ↗

A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients.Semantic proximity Read ↗

The angiotensin-I converting enzyme gene I/D variation contributes to end-stage renal disease risk in Chinese patients with type 2 diabetes receiving hemodialysis.Semantic proximity Read ↗

[The significance of deletion polymorphism in the ACE gene for progression of diabetic nephropathies treated with ACE inhibitors].Semantic proximity Read ↗

Angiotensin-converting enzyme gene I/D polymorphism and renal disease.Semantic proximity Read ↗

Deletion insertion polymorphism of the angiotensin converting enzyme gene and progression of diabetic nephropathy.Semantic proximity Read ↗

Lack of association between the insertion/deletion polymorphism of the angiotensin-converting-enzyme gene and diabetic nephropathy in IDDM patients.Semantic proximity Read ↗

Prognostic value of angiotensin-I converting enzyme I/D polymorphism for nephropathy in type 1 diabetes mellitus: a prospective study.Semantic proximity Read ↗

Meta-analysis of the relationship between ACE I/D gene polymorphism and end-stage renal disease in patients with diabetic nephropathy.Semantic proximity Read ↗

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