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Article

Polymorphisms in angiotensin-converting-enzyme gene and progression of IgA nephropathy.

Lancet (London, England) - 17 Jun 1995

Harden P N, Geddes C, Rowe P A, McIlroy J H, Boulton-Jones M, Rodger R S, Junor B J, Briggs J D, Connell J M, Jardine A G

Abstract excerpt

We have investigated the influence of the functional insertion (I) and deletion (D) polymorphism in intron 16 of the gene for angiotensin-converting enzyme (ACE) in a retrospective study of 100 patients with IgA nephropathy. There was no difference in genotype frequency compared with normal subjects. However, patients homozygous for the D allele tended to present at an earlier age (medians: DD, 33; ID, 34; II, 42...

Topics

Adult
Alleles
Base Sequence
Blood Pressure
Creatinine
DNA
DNA Primers
Genotype
Glomerulonephritis, IGA
Humans
Introns
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Peptidyl-Dipeptidase A

Polymorphism, Genetic

Retrospective Studies

Source

Identifiers

PMID: 7791440
DOI: 10.1016/s0140-6736(95)91088-3

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7791440-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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