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Accumulation of DNA damage in the organs of mice deficient in gamma-glutamyltranspeptidase.

Mutation research - 14 Feb 2000

Rojas E, Valverde M, Kala S V, Kala G, Lieberman M W

Abstract excerpt

We have used a differential alkaline single cell gel electrophoresis assay of DNA ("omet assay" at pH 13 and 12.3) to evaluate DNA damage as a function of age in mice with an inherited defect in gluthathione (GSH) metabolism. The mice are homozygous null for gamma-glutamyltranspeptidase (GGT), the enzyme responsible for initiating the catabolism of GSH, and paradoxically have reduced levels of GSH and cysteine in...

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PMID: 10751614
DOI: 10.1016/s0027-5107(99)00191-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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