Nitric oxide-induced homologous recombination in Escherichia coli is promoted by DNA glycosylases.

doi:10.1128/JB.184.13.3501-3507.2002

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Article

Nitric oxide-induced homologous recombination in Escherichia coli is promoted by DNA glycosylases.

Journal of bacteriology - 1 Jul 2002

Spek Erik J, Vuong Laurel N, Matsuguchi Tetsuya, Marinus Martin G, Engelward Bevin P

Abstract excerpt

Nitric oxide (NO*) is involved in neurotransmission, inflammation, and many other biological processes. Exposure of cells to NO* leads to DNA damage, including formation of deaminated and oxidized bases. Apurinic/apyrimidinic (AP) endonuclease-deficient cells are sensitive to NO* toxicity, which indicates that base excision repair (BER) intermediates are being generated. Here, we show that AP...

Topics

Carbon-Oxygen Lyases
DNA Damage
DNA Glycosylases
DNA Repair
DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA-Directed DNA Polymerase
DNA-Formamidopyrimidine Glycosylase
Escherichia coli
Escherichia coli Proteins
Exodeoxyribonuclease V

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Exodeoxyribonucleases

Mutation

N-Glycosyl Hydrolases

Nitric Oxide

Recombination, Genetic

Uracil-DNA Glycosidase

Source

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Identifiers

PMID: 12057944
DOI: 10.1128/JB.184.13.3501-3507.2002
PMCID: PMC135131

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