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Article

Interaction of PIP(2) with the XIP region of the cardiac Na/Ca exchanger.

American journal of physiology. Cell physiology - 1 Apr 2000

He Z, Feng S, Tong Q, Hilgemann D W, Philipson K D

Abstract excerpt

The sarcolemmal Na/Ca exchanger undergoes an inactivation process in which exchange activity decays over several seconds following activation by the application of Na to the intracellular surface of the protein. Inactivation is eliminated by an increase in membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)). Inactivation is also strongly affected by mutations to a basic 20-amino acid segment of the exchanger...

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Source

Identifiers

PMID: 10751315
DOI: 10.1152/ajpcell.2000.278.4.C661

Genes

PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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