Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influences of IGF-I gene disruption on the cellular profile of the diaphragm.

American journal of physiology. Endocrinology and metabolism - 1 Apr 2000

Fournier M, Lewis M I

Abstract excerpt

The impact of a targeted disruption of the Igf1 gene, encoding the insulin-like growth factor I (IGF-I), on diaphragm (DIA) cellularity was studied in 2-mo-old homozygous mutant [IGF-I(-/-)] mice and their wild-type [WT; i.e., IGF-I(+/+)] littermates. DIA fiber types were classified histochemically. DIA fiber cross-sectional areas (CSA) were determined from digitized muscle sections, and fiber succinate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capillaries
Share to Cell Count
Share to Diaphragm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor I

Share to Isomerism

Share to Muscle Fibers, Skeletal

Share to Myosin Heavy Chains

Share to Succinate Dehydrogenase

Source

Identifiers

PMID: 10751206
DOI: 10.1152/ajpendo.2000.278.4.E707

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influences of IGF-I gene disruption on the cellular profile of the diaphragm.PMID 10751206Read ↗

Knockout of Insulin-Like Growth Factor-1 Receptor Impairs Distal Lung MorphogenesisSemantic proximity Read ↗

IGF-I is required for normal embryonic growth in mice.Semantic proximity Read ↗

Essential Role of Insulin and Insulin-Like Growth Factor 1 Receptor Signaling in Cardiac Development and FunctionSemantic proximity Read ↗

Muscle-specific expression of insulin-like growth factor 1 improves outcome in Lama2Dy-w mice, a model for congenital muscular dystrophy type 1ASemantic proximity Read ↗

Effects of the compact mutant myostatin allele Mstn (Cmpt-dl1Abc) introgressed into a high growth mouse line on skeletal muscle cellularity.Semantic proximity Read ↗

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).Semantic proximity Read ↗

Elevated insulin-like growth factor 2 expression may contribute to the hypermuscular phenotype of myostatin null mice.Semantic proximity Read ↗

Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.Semantic proximity Read ↗

Myosin heavy chains IIa and IId are functionally distinct in the mouse.Semantic proximity Read ↗

Morphology and myofiber composition of skeletal musculature of the forelimb in young and aged wild type and myostatin null mice.Semantic proximity Read ↗

Diaphragm contractile dysfunction in MyoD gene-inactivated mice.Semantic proximity Read ↗

Apoptosis-inducing factor regulates skeletal muscle progenitor cell number and muscle phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.