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Article

Germline and somatic loss of function of the mouse cpk gene causes biliary ductal pathology that is genetically modulated.

Human molecular genetics - 22 Mar 2000

Guay-Woodford L M, Green W J, Lindsey J R, Beier D R

Abstract excerpt

The mouse cpk mutation is the most extensively characterized murine model of polycystic kidney disease (PKD) and closely resembles human autosomal recessive PKD (ARPKD), with the exception that B6-cpk/cpk homozygotes do not express the biliary ductal plate malformation (DPM) lesion. However, homozygous mutants from outcrosses to other strains, e.g. DBA/2J (D2), CD-1, BALB/c and Mus mus castaneus (CAST), express...

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Source

Identifiers

PMID: 10749984
DOI: 10.1093/hmg/9.5.769

Genes

CAST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Germline and somatic loss of function of the mouse cpk gene causes biliary ductal pathology that is genetically modulated.PMID 10749984Read ↗

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