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Article

Chromosome condensation factor Brn1p is required for chromatid separation in mitosis.

Molecular biology of the cell - 1 Apr 2000

Ouspenski I I, Cabello O A, Brinkley B R

Abstract excerpt

This work describes BRN1, the budding yeast homologue of Drosophila Barren and Xenopus condensin subunit XCAP-H. The Drosophila protein is required for proper chromosome segregation in mitosis, and Xenopus protein functions in mitotic chromosome condensation. Mutant brn1 cells show a defect in mitotic chromosome condensation and sister chromatid separation and segregation in anaphase. Chromatid cohesion before...

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Identifiers

PMID: 10749931
DOI: 10.1091/mbc.11.4.1305
PMCID: PMC14848

Genes

SMC2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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