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Article

Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2007

Krieger Nancy S, Frick Kevin K, LaPlante Strutz Kelly, Michalenka Anne, Bushinsky David A

Abstract excerpt

UNLABELLED: Chronic metabolic acidosis induces net Ca efflux from bone; this osteoclastic bone resorption is mediated by increased osteoblastic prostaglandin synthesis. Cyclooxygenase, the rate-limiting enzyme in prostaglandin synthesis, is present in both constitutive (COX-1) and inducible (COX-2) forms. We report here that acidosis increases both osteoblastic RNA and protein levels for COX-2 and that genetic...

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Source

Identifiers

PMID: 17352658
DOI: 10.1359/jbmr.070316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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