Article
Association of SRD5A2 genotype and pathological characteristics of prostate tumors.
Cancer research - 15 Mar 2000
Jaffe J M, Malkowicz S B, Walker A H, MacBride S, Peschel R, Tomaszewski J, Van Arsdalen K, Wein A J, Rebbeck T R
Abstract excerpt
The enzyme product of SRD5A2, 5alpha-reductase type II, is responsible for converting testosterone to the more metabolically active dihydrotestosterone. Therefore, SRDSA2 may be involved in the development or growth of prostate tumors. To examine the effects of allelic variants in the gene SRDSA2 on the presentation of prostate tumors, we studied a sample, primarily Caucasian, of 265 men with incident prostate...
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