Article
Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2001
Hsing A W, Chen C, Chokkalingam A P, Gao Y T, Dightman D A, Nguyen H T, Deng J, Cheng J, Sesterhenn I A, Mostofi F K, Stanczyk F Z, Reichardt J K
Abstract excerpt
It has been suggested that the activity of the steroid 5alpha-reductase type II enzyme (encoded by the SRD5A2 gene) may be associated with prostate cancer risk and that population differences in this enzyme's activity may account for part of the substantial racial/ethnic disparity in prostate cancer risk. To provide etiological clues, we evaluated the relationships of four polymorphic markers in the SRD5A2 gene,...
Topics
- Adult
- Age Distribution
- Aged
- Base Sequence
- Case-Control Studies
- Cholestenone 5 alpha-Reductase
- Confidence Intervals
- Genetic Markers
- Genetic Predisposition to Disease