Article
Polymorphism of the SRD5A2 gene and the risk of prostate cancer.
Molecular medicine reports - 1 Dec 2014
Dušenka Róbert, Tomaškin Roman, Kliment Ján, Dobrota Dušan, Dušenková Svetlana, Vilčková Marta, Sivoňová Monika Kmeť'ová
Abstract excerpt
Androgens are actively involved in the development of the prostate gland and appear to be essential for prostate carcinogenesis. The product of the SRD5A2 gene, membrane‑bound steroid 5‑α‑reductase, type II enzyme, is key in testosterone metabolism. The present study explored the association between the SRD5A2 V89L gene polymorphism and the risk of developing prostate cancer. The study cohort consisted of 456...
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