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Article

SRD5A2 gene polymorphisms and the risk of benign prostatic hyperplasia but not prostate cancer.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015

Choubey Vimal Kumar, Sankhwar Satya Narayan, Carlus S Justin, Singh Anand Narayan, Dalela Divakar, Thangaraj Kumarasamy, Rajender Singh

Abstract excerpt

BACKGROUND: Testosterone, a primary androgen in males, is converted into its most active form, dihydrotestosterone (DHT), by 5α-reductase type 2 (encoded by the SRD5A2 gene) in the prostate. DHT is necessary for prostatic growth and has five times higher binding affinity than testosterone for androgen receptors. We hypothesized that polymorphic variations in the SRD5A2 gene may affect the risk of benign prostatic...

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Identifiers

PMID: 25735326
DOI: 10.7314/apjcp.2015.16.3.1033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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