Article
Polymorphisms in the androgen receptor and type II 5 alpha-reductase genes and prostate cancer prognosis.
The Prostate - 1 Sept 2002
Shibata Atsuko, Garcia Maria Isabel, Cheng Iona, Stamey Thomas A, McNeal John E, Brooks James D, Henderson Stavonnie, Yemoto Cheryl E, Peehl Donna M
Abstract excerpt
BACKGROUND: Cytosine-adenine-guanine repeat length of the androgen receptor gene and the A49T and V89L polymorphisms of the 5 alpha-reductase (SRD5A2) gene have been associated with prostate cancer. METHODS: We investigated the relationship of the three genetic polymorphisms to tumor grade among 211 men who had undergone radical prostatectomy. Subjects had prostate cancer <3 cm(3) with a percentage of cancer...
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