Article
5alpha-reductase 2 polymorphisms as risk factors in prostate cancer.
Pharmacogenetics - 1 Jun 2002
Söderström Torbjörn, Wadelius Mia, Andersson Swen-Olov, Johansson Jan-Erik, Johansson Sara, Granath Fredrik, Rane Anders
Abstract excerpt
Prostate cancer is a significant cause of death in Western countries and is under the strong influence of androgens. The steroid 5alpha-reductase 2 catalyzes the metabolism of testosterone into the more potent androgen dihydrotestosterone in the prostate gland. The enzyme is a target in pharmacological treatment of benign prostatic hyperplasia using specific inhibitors such as finasteride. Makridakis et al. have...
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