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Article

Importance of 5α-reductase gene polymorphisms on circulating and intraprostatic androgens in prostate cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2014

Lévesque Éric, Laverdière Isabelle, Lacombe Louis, Caron Patrick, Rouleau Mélanie, Turcotte Véronique, Têtu Bernard, Fradet Yves, Guillemette Chantal

Abstract excerpt

PURPOSE: Polymorphisms in the genes SRD5A1 and SRD5A2 encoding androgen biosynthetic 5α-reductase enzymes have been associated with an altered risk of biochemical recurrence after radical prostatectomy in localized prostate cancer. EXPERIMENTAL DESIGN: To gain potential insights into SRD5A biologic effects, we examined the relationship between SRD5A prognostic markers and endogenous sex-steroid levels measured by...

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PMID: 24277450
DOI: 10.1158/1078-0432.CCR-13-1100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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