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Article

The fate of the initiator tRNAs is sensitive to the critical balance between interacting proteins.

The Journal of biological chemistry - 7 Jul 2000

Thanedar S, Kumar N V, Varshney U

Abstract excerpt

Formylation of the initiator tRNA is essential for normal growth of Escherichia coli. The initiator tRNA containing the U35A36 mutation (CUA anticodon) initiates from UAG codon. However, an additional mutation at position 72 (72A --> G) renders the tRNA (G72/U35A36) inactive in initiation because it is defective in formylation. In this study, we isolated U1G72/U35A36 tRNA containing a wobble base pair at 1-72...

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Share to Anticodon
Share to Carboxylic Ester Hydrolases
Share to Codon, Initiator

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Peptide Chain Initiation, Translational

Share to Peptide Initiation Factors

Share to RNA, Bacterial

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Source

Identifiers

PMID: 10748005
DOI: 10.1074/jbc.M001238200

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PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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