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Article

Yeast initiator tRNA identity elements cooperate to influence multiple steps of translation initiation.

RNA (New York, N.Y.) - 1 May 2006

Kapp Lee D, Kolitz Sarah E, Lorsch Jon R

Abstract excerpt

All three kingdoms of life employ two methionine tRNAs, one for translation initiation and the other for insertion of methionines at internal positions within growing polypeptide chains. We have used a reconstituted yeast translation initiation system to explore the interactions of the initiator tRNA with the translation initiation machinery. Our data indicate that in addition to its previously characterized role...

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Identifiers

PMID: 16565414
DOI: 10.1261/rna.2263906
PMCID: PMC1440903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Yeast initiator tRNA identity elements cooperate to influence multiple steps of translation initiation.PMID 16565414Read ↗

Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon.Semantic proximity Read ↗

Translation initiation factor 2gamma mutant alters start codon selection independent of Met-tRNA binding.Semantic proximity Read ↗

Escherichia coli initiator tRNA: structure-function relationships and interactions with the translational machinery.Semantic proximity Read ↗

Two highly conserved features of bacterial initiator tRNAs license them to pass through distinct checkpoints in translation initiation.Semantic proximity Read ↗

Sequential eukaryotic translation initiation factor 5 (eIF5) binding to the charged disordered segments of eIF4G and eIF2β stabilizes the 48S preinitiation complex and promotes its shift to the initiation mode.Semantic proximity Read ↗

Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome.Semantic proximity Read ↗

Activation of initiation factor 2 by ligands and mutations for rapid docking of ribosomal subunits.Semantic proximity Read ↗

Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo.Semantic proximity Read ↗

eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B.Semantic proximity Read ↗

Translation initiation at non-AUG codons mediated by weakened association of eukaryotic initiation factor (eIF) 2 subunits.Semantic proximity Read ↗

IF2 and unique features of initiator tRNAfMet help establish the translational reading frame.Semantic proximity Read ↗

Interaction between 25S rRNA A loop and eukaryotic translation initiation factor 5B promotes subunit joining and ensures stringent AUG selection.Semantic proximity Read ↗

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