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Article

Coupling between the N- and C-terminal domains influences transducin-alpha intrinsic GDP/GTP exchange.

Biochemistry - 11 Apr 2000

Muradov K G, Artemyev N O

Abstract excerpt

The N-terminal regions of the heterotrimeric G-protein alpha-subunits represent one of the major Gbetagamma contact sites and have been implicated in an interaction with G-protein-coupled receptors. To probe the role of the N-terminal domain of transducin-alpha in G-protein function, a chimeric Gtialpha subunit with the 31 N-terminal Gtalpha residues replaced by the corresponding 42 residues of Gsalpha...

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Identifiers

PMID: 10747781
DOI: 10.1021/bi992156l

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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